Now you don't have to just take our word for it.

The proof

There are countless summaries and even full studies available for free on the internet regarding the efficacy of Theobromine and Nano-hydroxyapatite, as well as for most of our ingredients!  I have compiled some here to help in the quest for better health. 

This is not the full article but a clip copied from the cover page.  You can access the full article at the link provided below


This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.


Acta Stomatol Croat. 2021 Mar; 55(1): 18–27.

doi: 10.15644/asc55/1/3

PMCID: PMC8033621

PMID: 33867534


Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results

Muesser Ahu Durhan,1 Seda Ozsalih,1 Berna Gokkaya,2 Pinar Yildiz Kulan,1 and Betul Kargul1




  "Enamel remineralizing effects of theobromine have received much attention from the clinicians. The aim of this study was to investigate the caries preventive effect of theobromine containing toothpaste on children with early childhood caries (ECC)."


Material and Methods


    "Salivary pH, buffering capacity and frequency of Streptococcus mutans (SM) levels were measured. Each child was assigned either fluoridated or theobromine containing toothpaste. The changes were analyzed using Laser Fluorescence system. Statistical analyses were performed."




  " We included 13 children (mean age 4.25) with 145 teeth in the fluoridated toothpaste (Colgate Kids toothpaste) group; 13 children (mean age 4.46) with 115 teeth in theobromine containing toothpaste (TheodentTMKids toothpaste) group. Both toothpastes demonstrated enamel remineralization and were effective in increasing the buffering capacity and pH (p < 0.05). A statistically significant decrease in S. mutans levels was found in both toothpaste groups (p<0.05)."



   "Both toothpaste group showed a statistically significant amount of enamel remineralization. Since theobromine had the added benefits of increasing the salivary pH and decreasing the S.mutans levels, theobromine containing toothpastes can be considered effective agents in remineralizing white spot lesions and can be used in prevention of early enamel lesions."

Additional quotes from this article:

"It is also a well-known fact that fluoride has a beneficial effect on slowing down the caries progression (4). While the use of fluoride is beneficial for strengthening the enamel, overexposure to fluoride carries the risk of fluorosis. An increased risk of dental and skeletal fluorosis is due to the ingestion of fluoride from different sources and from swallowing toothpaste with fluoride (5). Additionally, it has been disputed whether fluorides interact with ameloblasts, thus having adverse effects on the enamel formation (6)."

"Several studies comparing theobromine and hydroxyapatite were also conducted and the following results were obtained: a study which aimed to analyze and compare the effects of toothpastes containing theobromine and hydroxyapatite on enamel microhardness has found that enamel microhardness was increased significantly after brushing with both Theodent (theobromine) and Pepsodent (HAP) toothpastes. However, the enhancement of enamel hardness in specimens treated with HAP-containing toothpaste was superior to those treated with theobromine toothpaste." 32


This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.


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